For a single voxel, suppose $`\mathbf{y}_{n} \sim \text{multinomial}(\mathcal{\pi})`$, and $`p(\mathbf{x}^{L}_{n}|y_{nk}=1) = \mathcal{N}(\mu_{k}, \Sigma_{k}^{L})`$. To use high-quality data to inform the inference on low-quality data, we assume $`p(\mathbf{x}^{H}_{n}|y_{nk}=1, \mathbf{U}) = \mathcal{N}(\mathbf{U}\mathbf{x}^{H}_{n}|\mu_{k}, \Sigma_{k}^{H})`$ where $`\mathbf{U}^{T}\mathbf{U} = \mathbf{I}`$. The complete likelihood can be written as