melhlprfns.cc

/*  MELODIC - Multivariate exploratory linear optimized decomposition into 
              independent components
    
    melhlprfns.cc - misc functions

    Christian F. Beckmann, FMRIB Image Analysis Group
    
    Copyright (C) 1999-2008 University of Oxford */

/*  Part of FSL - FMRIB's Software Library
    http://www.fmrib.ox.ac.uk/fsl
    fsl@fmrib.ox.ac.uk
    
    Developed at FMRIB (Oxford Centre for Functional Magnetic Resonance
    Imaging of the Brain), Department of Clinical Neurology, Oxford
    University, Oxford, UK
    
    
    LICENCE
    
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    Oxford (the "Software")
    
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    University").
    
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    makes clear that no condition is made or to be implied, nor is any
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    You are not permitted under this Licence to use this Software
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#include "melhlprfns.h"
#include "libprob.h"
#include "miscmaths/miscprob.h"
#include "miscmaths/t2z.h"
#include "miscmaths/f2z.h"

namespace Melodic{

  void update_mask(volume<float>& mask, Matrix& Data)
  {
    Matrix DStDev=stdev(Data);
    volume4D<float> tmpMask, RawData;
    tmpMask.setmatrix(DStDev,mask);
    RawData.setmatrix(Data,mask);

    float tMmax;
    volume<float> tmpMask2;
    tmpMask2 = tmpMask[0];

    tMmax = tmpMask2.max();
    double st_mean = DStDev.Sum()/DStDev.Ncols();
    double st_std  = stdev(DStDev.t()).AsScalar();
      
    mask = binarise(tmpMask2,(float) max((float) st_mean-3*st_std,(float) 0.01*st_mean),tMmax);

    Data = RawData.matrix(mask);
  }

  void del_vols(volume4D<float>& in, int howmany)
  {
    for(int ctr=1; ctr<=howmany; ctr++){
	in.deletevolume(ctr);
    }    
  }

  Matrix calc_FFT(const Matrix& Mat, const bool logpwr)
  {
    Matrix res;
      for(int ctr=1; ctr <= Mat.Ncols(); ctr++){
	      ColumnVector tmpCol;  
	      tmpCol=Mat.Column(ctr);
	      ColumnVector FtmpCol_real;
	      ColumnVector FtmpCol_imag;
	      ColumnVector tmpPow;
	      if(tmpCol.Nrows()%2 != 0){
	        Matrix empty(1,1); empty=0;
	        tmpCol &= empty;
	      }
	      RealFFT(tmpCol,FtmpCol_real,FtmpCol_imag);
	      tmpPow = pow(FtmpCol_real,2)+pow(FtmpCol_imag,2);
	      tmpPow = tmpPow.Rows(2,tmpPow.Nrows());
	      if(logpwr) tmpPow = log(tmpPow);
	      if(res.Storage()==0){res= tmpPow;}else{res|=tmpPow;}
      }
      return res;
  }  //Matrix calc_FFT()

  Matrix smoothColumns(const Matrix& inp)
  {
    Matrix temp(inp);
    int ctr1 = temp.Nrows();
    Matrix temp2(temp);
    temp2=0;
    
    temp = temp.Row(4) & temp.Row(3) & temp.Row(2) & temp & temp.Row(ctr1-1) 
      & temp.Row(ctr1-2) &temp.Row(ctr1-3);
    
    double kern[] ={0.0045 , 0.055, 0.25, 0.4, 0.25, 0.055, 0.0045};
    double fac = 0.9090909;

    
    for(int cc=1;cc<=temp2.Ncols();cc++){
      for(int cr=1;cr<=temp2.Nrows();cr++){
	temp2(cr,cc) = fac*( kern[0] * temp(cr,cc) + kern[1] * temp(cr+1,cc) + 
			     kern[2] * temp(cr+2,cc) + kern[3] * temp(cr+3,cc) + 
			     kern[4] * temp(cr+4,cc) + kern[5] * temp(cr+5,cc) + 
			     kern[6] * temp(cr+6,cc));
      }
    }
    return temp2;
  }  //Matrix smoothColumns()

  Matrix convert_to_pbsc(Matrix& inp)
  {
    Matrix meanimg;
    meanimg = mean(inp);
    float eps = 0.00001;

    for(int ctr=1; ctr <= inp.Ncols(); ctr++){
      if(meanimg(1,ctr) < eps) 
	meanimg(1,ctr) = eps;
    }

    for(int ctr=1; ctr <= inp.Nrows(); ctr++){
      Matrix tmp;
      tmp << inp.Row(ctr);
      inp.Row(ctr) << 100 * SP((tmp - meanimg),pow(meanimg,-1));   
    }

    inp = remmean(inp);
    return meanimg;
  }  //void convert_to_pbsc   

  RowVector varnorm(Matrix& in, int dim, float level)
  {
    Matrix Corr;
    Corr = calc_corr(in);
    RowVector out;
    out = varnorm(in,Corr,dim,level);
    return out;
  }  //RowVector varnorm

	void varnorm(Matrix& in, const RowVector& vars)
	{
		Matrix tmp = vars;
		in = SP(in,pow(ones(in.Nrows(),1) * tmp,-1));
	}
	
  RowVector varnorm(Matrix& in, Matrix& Corr, int dim, float level)
  { 
    Matrix tmpE, white, dewhite;
    RowVector tmpD, tmpD2;

    std_pca(remmean(in,2), Corr, tmpE, tmpD);
    calc_white(tmpE,tmpD, dim, white, dewhite);
    
    Matrix ws = white * in;
    for(int ctr1 = 1; ctr1<=ws.Ncols(); ctr1++)
      for(int ctr2 = 1; ctr2<=ws.Nrows(); ctr2++)
				if(std::abs(ws(ctr2,ctr1)) < level)
	  			ws(ctr2,ctr1)=0;
    tmpD = stdev(in - dewhite*ws);
    for(int ctr1 = 1; ctr1<=tmpD.Ncols(); ctr1++)
      if(tmpD(ctr1) < 0.01){
				tmpD(ctr1) = 1.0;
				in.Column(ctr1) = 0.0*in.Column(ctr1);
      }
	  varnorm(in,tmpD);
    return tmpD;
  }  //RowVector varnorm

  Matrix SP2(const Matrix& in, const Matrix& weights, bool econ)
  {
    Matrix Res;
    Res = in;
    if(econ){
      ColumnVector tmp;
      for(int ctr=1; ctr <= in.Ncols(); ctr++){
	tmp = in.Column(ctr);
	tmp = tmp * weights(1,ctr);
	Res.Column(ctr) = tmp;
      }
    }
    else{
      Res = ones(in.Nrows(),1)*weights.Row(1);
      Res = SP(in,Res);
    }
    return Res;
  }  //Matrix SP

  Matrix corrcoef(const Matrix& in1, const Matrix& in2){
		Matrix tmp = in1;
		tmp |= in2;
		Matrix out;
		out=MISCMATHS::corrcoef(tmp,0);
		return out.SubMatrix(1,in1.Ncols(),in1.Ncols()+1,out.Ncols());
  }

  Matrix corrcoef(const Matrix& in1, const Matrix& in2, const Matrix& part){
	Matrix tmp1 = in1, tmp2 = in2, out;	
	if(part.Storage()){
		tmp1 = tmp1 - part * pinv(part) * tmp1;
		tmp2 = tmp2 - part * pinv(part) * tmp2;
	}
	
	out = corrcoef(tmp1,tmp2);
	return out;
  }

  Matrix calc_corr(const Matrix& in, bool econ)
  {
    Matrix Res;
    Res = zeros(in.Nrows(),in.Nrows());
    if(econ){
      ColumnVector tmp;
      for(int ctr=1; ctr <= in.Ncols(); ctr++){
	tmp = in.Column(ctr);
	tmp = tmp - mean(tmp).AsScalar();
	Res += (tmp * tmp.t()) / in.Ncols();
      }
    }
    else
      Res = cov(in.t());
    return Res;
  }  //Matrix calc_corr

  Matrix calc_corr(const Matrix& in, const Matrix& weights, bool econ)
  {
    Matrix Res;
    Res = zeros(in.Nrows(),in.Nrows());
    Matrix localweights;
    if(weights.Storage() == 0)
      localweights = ones(1,in.Ncols());
    else
      localweights = weights;
    if(econ){
      ColumnVector tmp;
      for(int ctr=1; ctr <= in.Ncols(); ctr++){
	tmp = in.Column(ctr);
	tmp = tmp - mean(tmp).AsScalar();
	tmp = tmp * localweights(1,ctr);
	Res += (tmp * tmp.t()) / in.Ncols();
      }
    }
    else{
      Res = SP2(in,localweights);
      Res = calc_corr(Res, 0); 
    }
    return Res;
  }  //Matrix calc_corr

  float calc_white(const Matrix& tmpE, const RowVector& tmpD, const RowVector& PercEV,  int dim, Matrix& param, Matrix& paramS, Matrix& white, Matrix& dewhite)
  {

//	tmpD2= tmpD | tmpPD.AsRow().Columns(tmpPE.Ncols()-param.Ncols()+1,tmpPE.Ncols());
//  cerr << tmpPD.AsRow().Columns(tmpPE.Ncols()-param.Ncols()+1,tmpPE.Ncols()) << endl;

//    

//	Matrix tmpPE;
//	tmpPE = SP(param,ones(param.Nrows(),1)*pow(stdev(param,1)*std::sqrt((float)param.Nrows()),-1));

//	RE |= tmpPE;
//	RowVector tmpD2;
//	tmpD2 = tmpD | stdev(param,1).AsRow()*std::sqrt((float)param.Nrows());
//	RD << abs(diag(tmpD2.t()));
//    RD << RD.SymSubMatrix(N-dim+1,N);

	Matrix RE;
    DiagonalMatrix RD;
    int N = tmpE.Ncols();
    dim = std::min(dim,N);

//	cerr << stdev(param) << endl;
    RE = tmpE.Columns(std::min(N-dim+1+param.Ncols(),N-2),N);
	RE |= param;

//	cerr << paramS.Nrows() << " x " << paramS.Ncols() << endl;
//	cerr << paramS << endl;
	RowVector tmpD2;
	tmpD2 = tmpD | pow(paramS,2).AsRow();
    RD << abs(diag(tmpD2.t()));

//	cerr << " " <<tmpD2.Ncols() << " " << N << " " << dim << endl;
    RD << RD.SymSubMatrix(N-dim+1+param.Ncols(),N+param.Ncols());    

    float res = 1.0;    
    white = sqrt(abs(RD.i()))*RE.t();
    dewhite = RE*sqrt(RD);

    if(dim < N)
      res = PercEV(dim);
    return res;
  }  //Matrix calc_white

  float calc_white(const Matrix& tmpE, const RowVector& tmpD, const RowVector& PercEV, int dim, Matrix& white, Matrix& dewhite)
  {
    Matrix RE;
    DiagonalMatrix RD;
    int N = tmpE.Ncols();
    dim = std::min(dim,N);
    RE = tmpE.Columns(N-dim+1,N);
    RD << abs(diag(tmpD.t()));
    RD << RD.SymSubMatrix(N-dim+1,N);    

    float res = 1.0;    
    white = sqrt(abs(RD.i()))*RE.t();
    dewhite = RE*sqrt(RD);

    if(dim < N)
      res = PercEV(dim);
    return res;
  }  //Matrix calc_white

  void calc_white(const Matrix& tmpE, const RowVector& tmpD, int dim, Matrix& white, Matrix& dewhite)
  {
    RowVector tmp(tmpE.Ncols());
    float tmp2;
    tmp2 = calc_white(tmpE,tmpD, tmp, dim, white, dewhite); 
  }  //Matrix calc_white

  void calc_white(const Matrix& tmpE, const RowVector& tmpD, int dim, Matrix& param, Matrix& paramS, Matrix& white, Matrix& dewhite)
  {
    RowVector tmp(tmpE.Ncols());
    float tmp2;
    tmp2 = calc_white(tmpE,tmpD, tmp, dim, param, paramS, white, dewhite); 
  }  //Matrix calc_white

  void calc_white(const Matrix& Corr, int dim, Matrix& white, Matrix& dewhite)
  {
    Matrix RE;
    DiagonalMatrix RD;
    SymmetricMatrix tmp;
    RowVector tmp2;
    tmp << Corr;
    EigenValues(tmp,RD,RE);
    tmp2 = diag(RD).t();
    calc_white(RE,tmp2, dim, white, dewhite); 
  }  //Matrix calc_white
  
 
  void std_pca(const Matrix& Mat, const Matrix& weights, Matrix& Corr, Matrix& evecs, RowVector& evals)
  {
    if(weights.Storage()>0)
      Corr << calc_corr(Mat, weights);
    else
      Corr << calc_corr(Mat);
    SymmetricMatrix tmp;
    tmp << Corr;
    DiagonalMatrix tmpD;
    EigenValues(tmp,tmpD,evecs);
    evals = tmpD.AsRow();
  }  //void std_pca

  void std_pca(const Matrix& Mat, Matrix& Corr, Matrix& evecs, RowVector& evals)
  {
    Matrix weights;
    std_pca(Mat,weights,Corr,evecs,evals);
  }  //void std_pca

  void em_pca(const Matrix& Mat, Matrix& evecs, RowVector& evals, int num_pc, int iter)
  {
    Matrix guess;
    guess = normrnd(Mat.Nrows(),num_pc);
    em_pca(Mat,guess,evecs,evals,num_pc,iter);
  }  //void em_pca

  void em_pca(const Matrix& Mat, Matrix& guess, Matrix& evecs, RowVector& evals, int num_pc, int iter)
  {
    Matrix C;
    if(guess.Ncols() < num_pc){
      C=normrnd(Mat.Nrows(),num_pc);
      C.Columns(1,guess.Ncols()) = guess;
    }
    else
      C = guess;

    Matrix tmp, tmp2;
    for(int ctr=1; ctr <= iter; ctr++){
      // E-Step
      tmp = C.t()*C;
      tmp = tmp.i();
      tmp = tmp * C.t();
      tmp = tmp * Mat;
      // M-Step
      tmp2 = tmp * tmp.t();
      tmp2 = tmp2.i();
      tmp2 = Mat*tmp.t()*tmp2;
      C = tmp2;
    }
    
    symm_orth(C);
    Matrix Evc, tmpC;
    RowVector Evl;
    tmp = C.t() * Mat;
    std_pca(tmp,tmpC,Evc,Evl);
    evals = Evl;
    evecs = C * Evc;
  }  //void em_pca

  float rankapprox(const Matrix& Mat, Matrix& cols, Matrix& rows, int dim)
  { 
    Matrix Corr, Evecs, tmpWM, tmpDWM, tmp;
    RowVector Evals;
    std_pca(Mat.t(), Corr, Evecs, Evals);
    calc_white(Corr, dim, tmpWM, tmpDWM);
    tmp = tmpWM * Mat.t();
    cols = tmp.t();
    rows << tmpDWM;
		float res;
		Evals=fliplr(Evals);
		res = sum(Evals.Columns(1,dim),2).AsScalar()/sum(Evals,2).AsScalar()*100;
		return res;
  } // rankapprox

  RowVector krfact(const Matrix& Mat, Matrix& cols, Matrix& rows)
  {
		Matrix out; RowVector res(Mat.Ncols());
    for(int ctr1 = 1; ctr1 <= Mat.Ncols(); ctr1++){
			Matrix tmpVals(cols.Nrows(),rows.Nrows());
			for(int ctr2 = 1; ctr2 <= rows.Nrows(); ctr2++)
	  		tmpVals.Column(ctr2) << Mat.SubMatrix(cols.Nrows() * 
				(ctr2 - 1) + 1,cols.Nrows()*ctr2 ,ctr1,ctr1);
	
			Matrix tmpcols, tmprows;
	 		res(ctr1) =rankapprox(tmpVals, tmpcols, tmprows);
			cols.Column(ctr1) = tmpcols;
			rows.Column(ctr1) = tmprows;
    }
		return res;
  } // krfact

  RowVector krfact(const Matrix& Mat, int colnum, Matrix& cols, Matrix& rows)
  {
		RowVector res;
    cols = zeros(colnum,Mat.Ncols());
    rows = zeros(int(Mat.Nrows() / colnum),Mat.Ncols());
    res = krfact(Mat,cols,rows);
		return res;
  } // krfact

  Matrix krprod(const Matrix& cols, const Matrix& rows)
  {
    Matrix out;
    out = zeros(cols.Nrows()*rows.Nrows(),cols.Ncols());
    for(int ctr1 = 1; ctr1 <= cols.Ncols(); ctr1++)
      for(int ctr2 = 1; ctr2 <= rows.Nrows(); ctr2++)
	{
	  out.SubMatrix(cols.Nrows()*(ctr2-1)+1,cols.Nrows()*ctr2,ctr1,ctr1) << cols.Column(ctr1) * rows(ctr2,ctr1);
	}
    return out;
  } // krprod

  Matrix krapprox(const Matrix& Mat, int size_cols, int dim)
  {
    Matrix out, cols, rows;
    out = zeros(Mat.Nrows(), Mat.Ncols());
    cols = zeros(size_cols,Mat.Ncols());
    rows = zeros(int(Mat.Nrows() / size_cols), Mat.Ncols());
    krfact(Mat,cols,rows);
    out = krprod(cols, rows);
    return out;
  } // krapprox

  void adj_eigspec(const RowVector& in, RowVector& out1, RowVector& out2, RowVector& out3, int& out4, int num_vox, float resels)
  {
    RowVector AdjEV;
    AdjEV << in.AsRow();
    AdjEV = AdjEV.Columns(3,AdjEV.Ncols());
    AdjEV = AdjEV.Reverse();

    RowVector CircleLaw;
    int NumVox = (int) floor(num_vox/(2.5*resels));

    CircleLaw = Feta(int(AdjEV.Ncols()), NumVox);

    for(int ctr=1;ctr<=CircleLaw.Ncols(); ctr++){
      if(CircleLaw(ctr)<5*10e-10){CircleLaw(ctr) = 5*10e-10;}
    } 

    /*    float slope;
    slope = CircleLaw.Columns(int(AdjEV.Ncols()/4),AdjEV.Ncols() - 
			      int(AdjEV.Ncols()/4)).Sum() /  
      AdjEV.Columns(int(AdjEV.Ncols()/4),AdjEV.Ncols() - 
      int(AdjEV.Ncols()/4)).Sum();*/

    RowVector PercEV(AdjEV);
    PercEV = cumsum(AdjEV / sum(AdjEV,2).AsScalar());

    AdjEV << SP(AdjEV,pow(CircleLaw.Columns(1,AdjEV.Ncols()),-1));

    SortDescending(AdjEV);
    int maxEV = 1;
    float threshold = 0.98;
    for(int ctr_i = 1; ctr_i < PercEV.Ncols(); ctr_i++){ 
      if((PercEV(ctr_i)<threshold)&&(PercEV(ctr_i+1)>=threshold)){maxEV=ctr_i;}
    }

    if(maxEV<3){maxEV=PercEV.Ncols()/2;}
    RowVector NewEV;
    Matrix temp1;
    temp1 = abs(AdjEV);
    NewEV << temp1.SubMatrix(1,1,1,maxEV);

    AdjEV = (AdjEV - min(AdjEV).AsScalar())/(max(AdjEV).AsScalar() - min(AdjEV).AsScalar());

    out1 = AdjEV;
    out2 = PercEV;
    out3 = NewEV;
    out4 = maxEV;
  }  //adj_eigspec

 void adj_eigspec(const RowVector& in, RowVector& out1, RowVector& out2)
  {
    RowVector AdjEV, PercEV;
    AdjEV = in.Reverse();
    SortDescending(AdjEV);
  
    PercEV = cumsum(AdjEV / sum(AdjEV,2).AsScalar());
    AdjEV = (AdjEV - min(AdjEV).AsScalar())/(max(AdjEV).AsScalar() - min(AdjEV).AsScalar());
    out1 = AdjEV;
    out2 = PercEV;
  }  //adj_eigspec

  RowVector Feta(int n1, int n2)
  {
    float nu = (float) n1/n2; 
    float bm = pow((1-sqrt(nu)),2.0);
    float bp = pow((1+sqrt(nu)),2.0);

    float lrange = 0.9*bm;
    float urange = 1.1*bp;

    RowVector eta(30*n1);
    float rangestepsize = (urange - lrange) / eta.Ncols(); 
    for(int ctr_i = 1; ctr_i <= eta.Ncols(); ctr_i++){ 
      eta(ctr_i) = lrange + rangestepsize * (ctr_i);
    }

    RowVector teta(10*n1);
    teta = 0;
    float stepsize = (bp - bm) / teta.Ncols();
    for(int ctr_i = 1; ctr_i <= teta.Ncols(); ctr_i++){ 
      teta(ctr_i) = stepsize*(ctr_i);
    }  
    
    RowVector feta(teta);
    feta = SP(pow(2*M_PI*nu*(teta + bm),-1), pow(SP(teta, bp-bm-teta),0.5));
   
    teta = teta + bm;

    RowVector claw(eta);
    claw = 0;
    for(int ctr_i = 1; ctr_i <= eta.Ncols(); ctr_i++){
      double tmpval = 0.0;
      for(int ctr_j = 1; ctr_j <= teta.Ncols(); ctr_j++){
	if(( double(teta(ctr_j))/double(eta(ctr_i)) )<1)
	  tmpval += feta(ctr_j);
      }
      claw(ctr_i) = n1*(1-stepsize*tmpval);
    }
    
    RowVector Res(n1); //invert the CDF
    Res = 0;
    for(int ctr_i = 1; ctr_i < eta.Ncols(); ctr_i++){ //Should this be <= instead of <?
      if(floor(claw(ctr_i))>floor(claw(ctr_i+1))){
	Res(int(floor(claw(ctr_i)))) = eta(ctr_i);
      }
    }
 
    return Res;
  }  //RowVector Feta

  RowVector cumsum(const RowVector& Inp)
  {
    UpperTriangularMatrix UT(Inp.Ncols());
    UT=1.0;
    RowVector Res;
    Res = Inp * UT;
    return Res;
  }  //RowVector cumsum

  int ppca_dim(const Matrix& in, const Matrix& weights, Matrix& PPCA, RowVector& AdjEV, RowVector& PercEV, Matrix& Corr, Matrix& tmpE, RowVector &tmpD, float resels, string which)
  {   
    std_pca(in,weights,Corr,tmpE,tmpD);

    int maxEV = 1;
    RowVector NewEV;
    adj_eigspec(tmpD.AsRow(),AdjEV,PercEV,NewEV,maxEV,in.Ncols(),resels);
    
    int res;
		PPCA = ppca_est(NewEV, in.Ncols(),resels);
    ColumnVector tmp = ppca_select(PPCA, res, maxEV, which);
		
		PPCA = tmp | PPCA;
    return res;
  }  //int ppca_dim

  int ppca_dim(const Matrix& in, const Matrix& weights, Matrix& PPCA, RowVector& AdjEV, RowVector& PercEV, float resels, string which)
  {   
    RowVector tmpD;
    Matrix tmpE;
    Matrix Corr;

    int res = ppca_dim(in, weights, PPCA, AdjEV, PercEV, Corr, tmpE, tmpD, resels, which);
    return res;
  }  //int ppca_dim

  int ppca_dim(const Matrix& in, const Matrix& weights, float resels, string which)
  {
    ColumnVector PPCA;
    RowVector AdjEV, PercEV;
    int res = ppca_dim(in,weights,PPCA,AdjEV,PercEV,resels,which);
    return res;
  }  //int ppca_dim

  ColumnVector ppca_select(Matrix& PPCAest, int& dim, int maxEV, string which)
  {
    RowVector estimators(5);
    estimators = 1.0;
    
    for(int ctr=1; ctr<=PPCAest.Ncols(); ctr++){
      PPCAest.Column(ctr) = (PPCAest.Column(ctr) - 
			   min(PPCAest.Column(ctr)).AsScalar()) / 
	( max(PPCAest.Column(ctr)).AsScalar() - 
	  min(PPCAest.Column(ctr)).AsScalar());
    }
    
    int ctr_i = 1;
    while((ctr_i< PPCAest.Nrows()-1)&&
	  (PPCAest(ctr_i,2) < PPCAest(ctr_i+1,2))&&(ctr_i<maxEV))
      {estimators(1)=ctr_i+1;ctr_i++;}
    ctr_i = 1;
    while((ctr_i< PPCAest.Nrows()-1)&&
	  (PPCAest(ctr_i,3) < PPCAest(ctr_i+1,3))&&(ctr_i<maxEV))
      {estimators(2)=ctr_i+1;ctr_i++;}
    ctr_i = 1;
    while((ctr_i< PPCAest.Nrows()-1)&&
	  (PPCAest(ctr_i,4) < PPCAest(ctr_i+1,4))&&(ctr_i<maxEV))
      {estimators(3)=ctr_i+1;ctr_i++;}
    ctr_i = 1;
    while((ctr_i< PPCAest.Nrows()-1)&&
	  (PPCAest(ctr_i,5) < PPCAest(ctr_i+1,5))&&(ctr_i<maxEV))
      {estimators(4)=ctr_i+1;ctr_i++;}
    ctr_i = 1;
    while((ctr_i< PPCAest.Nrows()-1)&&
	  (PPCAest(ctr_i,6) < PPCAest(ctr_i+1,6))&&(ctr_i<maxEV))
      {estimators(5)=ctr_i+1;ctr_i++;}

    int res = 0;
    ColumnVector PPCA;
 		RowVector PercEV(PPCAest.Column(1).t());
	  PercEV = cumsum(PercEV / sum(PercEV,2).AsScalar());

		if(which == string("aut"))
			if(int(estimators(2)) < int(estimators(1)) && 
				float(PercEV(int(estimators(2))))>0.8){
				res=int(estimators(2));
	      PPCA << PPCAest.Column(3);
			}else{
				res = int(estimators(1));
	      PPCA << PPCAest.Column(2);
			}				
    if(which == string("lap")){
      res = int(estimators(1));
      PPCA << PPCAest.Column(2);
    }
    if(which == string("bic")){
      res = int(estimators(2));
      PPCA << PPCAest.Column(3);
    }
    if(which == string("mdl")){
      res = int(estimators(3));
      PPCA << PPCAest.Column(4);
    }
    if(which == string("rrn")){
      res = int(estimators(4));
      PPCA << PPCAest.Column(5);
    }
    if(which == string("aic")){
      res = int(estimators(5));
      PPCA << PPCAest.Column(6);
    }
		if(which == string("median")){
			RowVector unsorted(estimators);	
			SortAscending(unsorted);
			ctr_i=1;
			res=int(unsorted(3));
			while(res != int(estimators(ctr_i)))			
				ctr_i++;
			PPCA << PPCAest.Column(ctr_i);
		}
    if(res==0 || which == string("mean")){//median estimator
      PPCA = mean(PPCAest.Columns(2,6),2);
			res=int(mean(estimators,2).AsScalar());
    }

    dim = res;
    return PPCA;
  }  //RowVector ppca_select

  Matrix ppca_est(const RowVector& eigenvalues, const int N1, const float N2)
  { 
    Matrix Res;
    Res = ppca_est(eigenvalues, (int) floor(N1/(2.5*N2)));
    return Res;
  }  //Matrix ppca_est

  Matrix ppca_est(const RowVector& eigenvalues, const int N)
  {
    RowVector logLambda(eigenvalues);
    logLambda = log(eigenvalues);

    int d = logLambda.Ncols();

    RowVector k(d);
    for(int ctr_i = 1; ctr_i <=d; ctr_i++){
      k(ctr_i)=ctr_i;
    }
   
    RowVector m(d);
    m=d*k-0.5*SP(k,k+1); 

    RowVector loggam(d);
    loggam = 0.5*k.Reverse();
    for(int ctr_i = 1; ctr_i <=d; ctr_i++){
      loggam(ctr_i)=lgam(loggam(ctr_i));
    }
    loggam = cumsum(loggam); 

    RowVector l_probU(d);
    l_probU = -log(2)*k + loggam - cumsum(0.5*log(M_PI)*k.Reverse());

    RowVector tmp1;
    tmp1 = -cumsum(eigenvalues).Reverse()+sum(eigenvalues,2).AsScalar();
    tmp1(1) = 0.95*tmp1(2);
    tmp1=tmp1.Reverse();

    RowVector tmp2;
    tmp2 = -cumsum(logLambda).Reverse()+sum(logLambda,2).AsScalar();
    tmp2(1)=tmp2(2);
    tmp2=tmp2.Reverse();

    RowVector tmp3;
    tmp3 = d-k;
    tmp3(d) = 1.0;

    RowVector tmp4;
    tmp4 = SP(tmp1,pow(tmp3,-1));    
    for(int ctr_i = 1; ctr_i <=d; ctr_i++){
      if(tmp4(ctr_i)<0.01){tmp4(ctr_i)=0.01;}
      if(tmp3(ctr_i)<0.01){tmp3(ctr_i)=0.01;}
      if(tmp1(ctr_i)<0.01){tmp1(ctr_i)=0.01;}
    }

    RowVector l_nu;
    l_nu = SP(-N/2*(d-k),log(tmp4));
    l_nu(d) = 0;

    RowVector l_lam;
    l_lam = -(N/2)*cumsum(logLambda);

    RowVector l_lhood;
    l_lhood = SP(pow(tmp3,-1),tmp2)-log(SP(pow(tmp3,-1),tmp1));

    Matrix t1,t2, t3;
    UpperTriangularMatrix triu(d);
    triu = 1.0;
    for(int ctr_i = 1; ctr_i <= triu.Ncols(); ctr_i++){
      triu(ctr_i,ctr_i)=0.0;
    }
    t1 = (ones(d,1) * eigenvalues);
    t1 = SP(triu,t1.t() - t1);
    t2 = pow(tmp4,-1).t()*ones(1,d);
    t3 = ones(d,1)*pow(eigenvalues,-1);
    t2 = SP(triu, t2.t()-t3.t());
    for(int ctr_i = 1; ctr_i <= t1.Ncols(); ctr_i++){
      for(int ctr_j = 1; ctr_j <= t1.Nrows(); ctr_j++){
	if(t1(ctr_j,ctr_i)<=0){t1(ctr_j,ctr_i)=1;}
      } 
    }
    for(int ctr_i = 1; ctr_i <= t2.Ncols(); ctr_i++){
      for(int ctr_j = 1; ctr_j <= t2.Nrows(); ctr_j++){
	if(t2(ctr_j,ctr_i)<=0){t2(ctr_j,ctr_i)=1;}
      }
    } 
    t1 = cumsum(sum(log(t1),2).AsRow());
    t2 = cumsum(sum(log(t2),2).AsRow());

    RowVector l_Az(d);
    l_Az << (t1+t2);

    RowVector l_lap;
    l_lap = l_probU + l_nu +l_Az + l_lam + 0.5*log(2*M_PI)*(m+k)-0.5*log(N)*k;
 
    RowVector l_BIC;
    l_BIC = l_lam + l_nu - 0.5*log(N)*(m+k);

    RowVector l_RRN;
    l_RRN = -0.5*N*SP(k,log(SP(cumsum(eigenvalues),pow(k,-1))))+l_nu;

    RowVector l_AIC;
    l_AIC = -2*N*SP(tmp3,l_lhood)+ 2*(1+d*k+0.5*(k-1));
    l_AIC = -l_AIC;

    RowVector l_MDL;
    l_MDL = -N*SP(tmp3,l_lhood)+ 0.5*(1+d*k+0.5*(k-1))*log(N);
    l_MDL = -l_MDL;

    Matrix Res;

    Res = eigenvalues.t();
    Res |= l_lap.t();
    Res |= l_BIC.t();
    Res |= l_MDL.t();
    Res |= l_RRN.t();
    Res |= l_AIC.t();
    
   
    return Res;
  }  //Matrix ppca_est

  ColumnVector acf(const ColumnVector& in, int order)
  {
    double meanval;
    meanval = mean(in).AsScalar();
    int tpoints = in.Nrows();
    
    ColumnVector y, res;
    Matrix X, tmp;

    y = in.Rows(order+1,tpoints) - meanval;
    X = zeros(order + 1, order);
    for(int ctr1 = 1; ctr1 <= order; ctr1++)
      X.Column(ctr1) = in.Rows(order + 1 - ctr1, tpoints - ctr1) - meanval;
    tmp = X.t()*X;
    tmp = tmp.i();
    tmp = tmp * X.t();
    res << tmp * y;
    return res;
  }  //ColumnVector acf

  ColumnVector pacf(const ColumnVector& in, int maxorder)
  {
    int tpoint = in.Nrows();
    ColumnVector res;
    res = acf(in, maxorder);
    for(int ctr1 = 1; ctr1 <= maxorder; ctr1++)
      if ( res.Column(ctr1).AsScalar() <  (1/tpoint) + 2/(float)std::pow(tpoint,0.5)) 
	res.Column(ctr1) = 0;
    return res;
  }  //ColumnVector pacf
  
  Matrix est_ar(const Matrix& Mat, int maxorder)
  {
    Matrix res;
    res = zeros(maxorder, Mat.Ncols());
    ColumnVector tmp;
    for (int ctr = 1; ctr <= Mat.Ncols(); ctr++){
      tmp = pacf(Mat.Column(ctr));
      res.Column(ctr) = tmp;
    }
    return res;
  }  //Matrix est_ar

  ColumnVector gen_ar(const ColumnVector& in, int maxorder)
  {
    float sdev;
    sdev = stdev(in).AsScalar();
    ColumnVector x, arcoeff, scaled;
    scaled = in / sdev;
    arcoeff = pacf( scaled, maxorder);
    x = normrnd(in.Nrows(),1).AsColumn() * sdev;
    for(int ctr1=2; ctr1 <= in.Nrows(); ctr1++)
      for(int ctr2 = 1; ctr2 <= maxorder; ctr2++)
	x(ctr1) = arcoeff(ctr2) * x(std::max(1,int(ctr1-ctr2))) + x(ctr1);
    return x;
  }  //ColumnVector gen_ar

  Matrix gen_ar(const Matrix& in, int maxorder)
  {
    Matrix res;
    res = in;
    ColumnVector tmp;
    for(int ctr=1; ctr <= in.Ncols(); ctr++){
      tmp = in.Column(ctr);
      res.Column(ctr) = gen_ar(tmp, maxorder);
    } 
    return res;
  }  //Matrix gen_ar

  Matrix gen_arCorr(const Matrix& in, int maxorder)
  {
    Matrix res;
    res = zeros(in.Nrows(), in.Nrows());
    ColumnVector tmp;
    for(int ctr=1; ctr<= in.Ncols(); ctr++){
      tmp = in.Column(ctr);
      tmp = gen_ar(tmp, maxorder);
      res += tmp * tmp.t();
    }
    return res;
  }  //Matrix gen_arCorr

	void basicGLM::olsfit(const Matrix& data, const Matrix& design, 
		const Matrix& contrasts, int DOFadjust)
	{
		beta = zeros(design.Ncols(),1); 
		residu = zeros(1); sigsq = -1.0*ones(1); varcb = -1.0*ones(1); 
		t = zeros(1); z = zeros(1); p=-1.0*ones(1);
		dof = (int)-1; cbeta = -1.0*ones(1); 

		if(data.Nrows()==design.Nrows()){
			Matrix dat = data;
			Matrix tmp = design.t()*design;
			Matrix pinvdes = tmp.i()*design.t();
			
			beta = pinvdes * dat;
			residu = dat - design*beta;

			dof = design.Nrows() - design.Ncols()-1;
			sigsq = sum(SP(residu,residu))/dof;
			
			float fact = float(dof) / design.Ncols();
			f_fmf =  SP(sum(SP(design*beta,design*beta)),pow(sum(SP(residu,residu)),-1)) * fact;
		
			pf_fmf = f_fmf.Row(1); 
			for(int ctr1=1;ctr1<=f_fmf.Ncols();ctr1++)
				pf_fmf(1,ctr1) = 1.0-MISCMATHS::fdtr(design.Ncols(),
				int(design.Nrows() -1 -design.Ncols()),f_fmf.Column(ctr1).AsScalar());
				
			if(contrasts.Storage()>0 && contrasts.Ncols()==beta.Nrows()){
				cbeta = contrasts*beta;
				Matrix tmp = contrasts*pinvdes*pinvdes.t()*contrasts.t();
				varcb = diag(tmp)*sigsq;
				t = SP(cbeta,pow(varcb,-0.5));
				z = t; p=t; 
				for(int ctr1=1;ctr1<=t.Ncols();ctr1++){
					ColumnVector tmp = t.Column(ctr1);
					T2z::ComputeZStats(varcb.Column(ctr1),cbeta.Column(ctr1),dof, tmp);
					z.Column(ctr1) << tmp;
					T2z::ComputePs(varcb.Column(ctr1),cbeta.Column(ctr1),dof, tmp);
					p.Column(ctr1) << exp(tmp);
				}
			}
		}	
	
	}


}